This session will focus on the pivotal role of the end-user experience in successful Manufacturing Execution System (MES) implementations. We will examine how involving end users from the design phase through to execution can significantly enhance system adoption, minimize deviations, and boost operational efficiency. By drawing on best practices from Novo Nordisk CMC Operations, we will showcase how user-friendly solutions can streamline workflows and save valuable time. Additionally, we will highlight the importance of engaging Line of Business and IT/OT teams to emphasize system functionality and ensure effective training throughout the implementation process.